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Hydrodynamic forces influence the gene transcription of mechanosensitive intercellular junction associated genes in corneal endothelial cells.
Anney P, Thériault M, Proulx S. Anney P, et al. Exp Eye Res. 2021 May;206:108532. doi: 10.1016/j.exer.2021.108532. Epub 2021 Mar 6. Exp Eye Res. 2021. PMID: 33684456 Review.
For native endothelia, hydrodynamic forces increased gene expression of GJA1 (connexin 43), CDH2 (N-cadherin), TJP1 (ZO-1), ITGAV (integrin subunit alphav), ITGB5 (integrin subunit beta5) and CTNND1 (p120-ctn) by 1.68 0.40, 1.10 0.27, 3.80 0.56, 1.82 0.33, 1.32 0.21 …
For native endothelia, hydrodynamic forces increased gene expression of GJA1 (connexin 43), CDH2 (N-cadherin), TJP1 (ZO-1), ITGAV (in …
Genome-wide meta-analysis, functional genomics and integrative analyses implicate new risk genes and therapeutic targets for anxiety disorders.
Li W, Chen R, Feng L, Dang X, Liu J, Chen T, Yang J, Su X, Lv L, Li T, Zhang Z, Luo XJ. Li W, et al. Nat Hum Behav. 2024 Feb;8(2):361-379. doi: 10.1038/s41562-023-01746-y. Epub 2023 Nov 9. Nat Hum Behav. 2024. PMID: 37945807
Integrative analyses, including transcriptome-wide association study, proteome-wide association study and colocalization analyses, prioritized potential causal genes (including CTNND1 and RAB27B). Evidence from multiple analyses revealed possibly causal genes, including RA …
Integrative analyses, including transcriptome-wide association study, proteome-wide association study and colocalization analyses, prioritiz …
Role of ARPC2 in Human Gastric Cancer.
Zhang J, Liu Y, Yu CJ, Dai F, Xiong J, Li HJ, Wu ZS, Ding R, Wang H. Zhang J, et al. Mediators Inflamm. 2017;2017:5432818. doi: 10.1155/2017/5432818. Epub 2017 Jun 13. Mediators Inflamm. 2017. PMID: 28694563 Free PMC article.
In this study, we found that ARPC2 promoted cell proliferation and invasion in the human cancer cell line MKN-28 using a cell total number assay, MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide) assay, cell colony formation assay, migration assay, invasion …
In this study, we found that ARPC2 promoted cell proliferation and invasion in the human cancer cell line MKN-28 using a cell total number a …
Hypergravity Increases Blood-Brain Barrier Permeability to Fluorescent Dextran and Antisense Oligonucleotide in Mice.
Dubayle D, Vanden-Bossche A, Peixoto T, Morel JL. Dubayle D, et al. Cells. 2023 Feb 24;12(5):734. doi: 10.3390/cells12050734. Cells. 2023. PMID: 36899870 Free PMC article.
Only the 70 kDa dextran and AS were detected in the parenchyma of several brain regions, suggesting an alteration in the BBB. Moreover, Ctnnd1, Gja4 and Actn1 were upregulated, whereas Jup, Tjp2, Gja1, Actn2, Actn4, Cdh2 and Ocln genes were downregulated, specifical …
Only the 70 kDa dextran and AS were detected in the parenchyma of several brain regions, suggesting an alteration in the BBB. Moreover, C …
Epithelial or mesenchymal: Where to draw the line?
Chai JY, Modak C, Mouazzen W, Narvaez R, Pham J. Chai JY, et al. Biosci Trends. 2010 Jun;4(3):130-42. Biosci Trends. 2010. PMID: 20592463 Free article.
In comparison, mesenchymal markers showed more fidelity, but CDH2 and MMP9 were still significantly higher in epithelial cells than in mesenchymal cells. Furthermore, TGFbeta1 up-regulated epithelial markers CTNNB1 and CTNND1, but suppressed mesenchymal markers, suc …
In comparison, mesenchymal markers showed more fidelity, but CDH2 and MMP9 were still significantly higher in epithelial cells than i …
Changes in the transcriptome of the human endometrial Ishikawa cancer cell line induced by estrogen, progesterone, tamoxifen, and mifepristone (RU486) as detected by RNA-sequencing.
Tamm-Rosenstein K, Simm J, Suhorutshenko M, Salumets A, Metsis M. Tamm-Rosenstein K, et al. PLoS One. 2013 Jul 16;8(7):e68907. doi: 10.1371/journal.pone.0068907. Print 2013. PLoS One. 2013. PMID: 23874806 Free PMC article.
RU486 did not appear to act as a pure antagonist of P4 and a functional analysis of RU486 response identified genes related to adhesion and apoptosis, including down-regulated genes associated with cell-cell contacts and adhesion as CTNND1, JUP, CDH2, IQGAP1, and CO …
RU486 did not appear to act as a pure antagonist of P4 and a functional analysis of RU486 response identified genes related to adhesion and …
Cathelicidin Treatment Silences Epithelial-Mesenchymal Transition Involved in Pulmonary Fibrosis in a Murine Model of Hypersensitivity Pneumonitis.
Lemieszek MK, Golec M, Zwoliński J, Dutkiewicz J, Milanowski J. Lemieszek MK, et al. Int J Mol Sci. 2022 Oct 27;23(21):13039. doi: 10.3390/ijms232113039. Int J Mol Sci. 2022. PMID: 36361827 Free PMC article.
Simultaneously, cathelicidin administered together or after SE-PA decreased the elevated level of myofibroblast markers (Acta2/alpha-smooth muscle actin, Cdh2/N-cadherin, Fn1/Fibronectin, Vim/vimentin) and increased the lowered level of epithelial markers (Cdh1/E-cadherin, …
Simultaneously, cathelicidin administered together or after SE-PA decreased the elevated level of myofibroblast markers (Acta2/alpha-smooth …
p120-Catenin is required for mouse vascular development.
Oas RG, Xiao K, Summers S, Wittich KB, Chiasson CM, Martin WD, Grossniklaus HE, Vincent PA, Reynolds AB, Kowalczyk AP. Oas RG, et al. Circ Res. 2010 Mar 19;106(5):941-51. doi: 10.1161/CIRCRESAHA.109.207753. Epub 2010 Jan 28. Circ Res. 2010. PMID: 20110533 Free PMC article.